1. UNRAVELLING THE FUNDAMENTALS OF GLUCOCORTICOID ACTIONS ACROSS VERTEBRATES

1.1 Mechanism(s) of glucocorticoid incorporation

How and to what extent are glucocorticoids synthesized and transported from the blood to other tissues focusing on fish scales, feathers and hair in the framework of chronic stress quantification?

1.2 Chronic stress, target glucocorticoid receptor profiles and ligand binding kinetics

How and to what extent can glucocorticoids other than the dominant hormone bind to glucocorticoid and mineralocorticoid receptors?

1.3 Extra-interrenal and -adrenal glucocorticoids and alternative substrates for glucocorticoid biosynthesis

How and to what extent influence extra-interrenal and -adrenal glucocorticoid biosynthesis the level of HPI and HPA produced glucocorticoids?

1.4 Glucocorticoid-mediated developmental programming and early life stress

How and to what extent can glucocorticoids deposited in the egg due to maternal transition and early life stressors influence the ontogeny of the HPI axis in fish?

1.5 Glucocorticoid-mediated bone (de)formation

How and to what extent do glucocorticoids affect bone (de)formation?

1.6 Individual variation in stress response

How and to what extent can individual variation in stress response and coping style be optimized to improve fish performance?